Immunosuppressive IDO1 and TDO Expression in Pediatric Central Nervous System Tumors

2nd Annual CBTTC Investigator Meeting, The Westin New Orleans Canal Place, New Orleans

May 25, 2016
Rishi Lulla, MS, MD, Ann and Robert Lurie Children’s Hospital of Chicago


Indoleamine 2,3 dioxygenase 1 (IDO1) and tryptophan dioxygenase (TDO) are highly immunosuppressive tryptophan catabolic enzymes that contribute to the recruitment of regulatory T-cells (Tregs; >CD4+CD25+FoxP3+) and/or suppress the immune response against central nervous tumors (CNS) tumors. This research aims to describe whether IDO1 and TDO were present in pediatric CNS tumors, as well as their overall relative expression levels for data generated from cells lines (n=5) and patient tumor specimens from the CBTTC (n=33).