Dictionary of Terms

Acronym Dictionary

CBTTC – Children’s Brain Tumor Tissue Consortium
PNOC – Pacific Pediatric Neuro-Oncology Consortium
CHOP – Children’s Hospital of Philadelphia
BioRC – BioRepository Core (The core collects and organizes biospecimens to serve all of the CBTTC’s biobanking needs while providing broad access to data and materials.)
LIMS – Laboratory Information Management System (i.e. Nautilus) (A general-purpose database that tracks biospecimens and promotes regulatory compliance while excluding any subject’s patient health information.)
SDG ID – “Sample Delivery Group”; aka the clinical event ID (The ID (i.e. “7316-###) associated with biospecimens obtained from a clinical event and used to identify biospecimens in Nautilus.)
BRP – BioRepository Portal (Portal used to associate the SDG ID to a subject’s health records.)
BGI – Beijing Genomics Institute
CNGB  China National Genebank
UPMC – University of Pittsburgh Medical Center
UCSC – University of California, Santa Cruz
UCSF – University of California San Francisco
COG – Children’s Oncology Group (CHOP)
CCCR – Center for Childhood Cancer Research (CHOP)

Tumor Type

DIPG (Diffuse Intrinsic Pontine Glioma) – A highly aggressive Grade IV astrocytoma typically located in the pons of the brainstem and are diffusely infiltrating which makes these tumors inoperable.

HGG (High Grade Glioma) – Highly malignant solid tumors arising from transformed cells of the brain and/or spinal cord (also called primary CNS tumors); Grade III and IV.

LGG (Low Grade Glioma) – Tumors arising from glial cells and categorized as Grade I and II; most low-grade gliomas are highly treatable and highly curable.

ATRT (Atypical Teratoid Rhaboid Tumor) – A rare, fast-growing, Grade IV tumor typically presented as a brain tumor, but can occur anywhere in the central nervous system; represents 3% of pediatric cancers of CNS.

DNET (Dysembryoplastic Neuroepithelial Tumor) – Glioneuronal tumors most commonly classified as benign tumours; Grade I of the WHO classification.

PNET (Primitive Neuroectodermal Tumor) – A malignant, Grade IV tumor derived from the neuroectoderm; typically presented in the cerebrum, but can spread to other parts of the brain/spine.

MPNST (Malignant Peripheral Nerve Sheath Tumor) – Also known as “malignant schwannoma”, “neurofibrosarcoma”, and “neurosarcoma”; a cancer of the connective tissue surrounding nerves.