About the CBTTC
The Children’s Brain Tumor Tissue Consortium (CBTTC) is a collaborative, multi-institutional research program dedicated to the study and treatment of childhood brain tumors. The CBTTC supports the research of new prognostic biomarkers and therapies for children with pediatric brain tumors. As part of this research effort, the CBTTC has developed a network of informatics and data applications which allow researchers from across the world to work together to discover cures. “Innovation through collaboration” is made possible by the CBTTC’s state-of-the-art biorepository as well as expertise of leaders in the field of biomedicine.
The CBTTC consists of 15 primary member institutions including: 1) Children’s Hospital of Philadelphia, 2) Seattle Children’s, 3) The Children’s Hospital of Pittsburgh and 4)Ann & Robert H. Lurie Children’s Hospital of Chicago, 5) Benioff Children’s Hospital (UCSF), 6) Stanford University/Lucile Packard Children’s Hospital, 7) Meyer Children’s Hospital Florence Italy, 8) Cancer Institute of New Jersey (Rutgers), 9)Weill Cornell Medicine Pediatric Brain and Spine Center, 10) Children’s National Health System, 11) Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, 12) Children’s Hospital of Orange County: CHOC Children’s, 13) University of California Santa Cruz – Treehouse Childhood Cancer Initiative 14) The Beijing Tiantan Hospital Neurosurgery Center (Beijing, China) and 15) Genebank (Beijing Genomics Institute – Shenzhen, China).
The operations center of the CBTTC is located at Children’s Hospital of Philadelphia and integrates genomic and molecular research, biorepository management and support for the informatics platforms of the CBTTC. This infrastructure serves an important role in the CBTTC’s ability to provide free and open access to brain tumor data to researchers throughout the world.
The mission of the CBTTC is to find cures and improve treatments for children diagnosed with brain tumors.
To achieve this mission, the CBTTC collects high-quality brain tumor biospecimens and associated clinical data to facilitate the genomic analysis of biospecimens. Cell lines are developed and transplantable tumor models are then created from biopsy specimens. These models allow researchers to share their findings with other CBTTC member institutions and with the world-wide scientific community.
The CBTTC has established a collaborative multi-institutional tissue and data repository to enable the collection and analysis of the high-quality brain tumor biopsy specimens. In addition to specimen data, the repository also links to clinical data to provide a comprehensive snapshot of each unique tumor.
Additionally, the CBTTC is committed to the advancement of tissue-based research, allowing researchers throughout the world to access molecular analysis of brain tumor specimens. These initiatives will allow for improvements in therapeutic treatment of patients diagnosed with a brain tumor.
The Executive Board is the entity responsible for oversight of the CBTTC. Executive Committee Members are:
|Jay Storm||Children’s Hospital of Philadelphia||Member|
|Adam Resnick||Children’s Hospital of Philadelphia||Scientific Co-Chair; PI from core institution|
|Angela Waanders||Children’s Hospital of Philadelphia||Member; PI from core institution|
|Michael Fisher||Children’s Hospital of Philadelphia||Member|
|Jena Lilly||Children’s Hospital of Philadelphia||Member|
|Ian Pollack||The Children’s Hospital of Pittsburgh||Member; PI from core institution|
|Ron Hamilton||The Children’s Hospital of Pittsburgh||Member|
|Sarah Leary||Seattle Children’s Hospital||Member; PI from core institution|
|Russ Geyer||Seattle Children’s Hospital||Member|
|Stewart Goldman||Ann and Robert H. Lurie Children’s Hospital of Chicago||Member|
|Rishi Lulla||Ann and Robert H. Lurie Children’s Hospital of Chicago||Executive Chair; PI from core institution|
|Jason Fangusaro||Ann and Robert H. Lurie Children’s Hospital of Chicago||Member|
|Joanna Phillips||UCSF Benioff Children’s Hospital||Member; Co-PI from core institution|
|Sabine Mueller||UCSF Benioff Children’s Hospital||Member; Co-PI from core institution|
|Brian Rood||Children’s National Health System||Member; Co-PI from core institution|
|Javad Nazarian||Children’s National Health System||Scientific Co-Chair; Co-PI from core institution|
|Gerald Grant||Stanford Medicine||Member; PI from core institution|
|Michelle Monje||Stanford Medicine||Member; Co-PI from core institution|
|Jeff Greenfied||Weill Cornell Medicine||Member; PI from core institution|
|Anita Nirenberg||Children’s Brain Tumor Foundation (CBTF)||Member; CBTF representative/ Community representative|
The CBTTC Scientific Committee acts as a body that provides oversight for the functioning of the CBTTC. This oversight includes the assessment and approval of specimen and data requests, recommendations regarding specimen analysis and storage, and review and approval of all proposed posters, abstracts, publications, etc. utilizing CBTTC Repository specimens and data.
|Ronald Hamilton||The Children’s Hospital of Pittsburgh||Member|
|Kimberly Diamond||The Children’s Hospital of Pittsburgh||Member|
|Ian Pollack||The Children’s Hospital of Pittsburgh||Member|
|Gary Kohanbash||The Children’s Hospital of Pittsburgh||Member|
|Sameer Agnihotri||The Children’s Hospital of Pittsburgh||Member|
|Adam Resnick||Children’s Hospital of Philadelphia||Co-Chair|
|Mariarita Santi-Vicini||Children’s Hospital of Philadelphia||Member|
|Jay Storm||Children’s Hospital of Philadelphia||Member|
|Angela Waanders||Children’s Hospital of Philadelphia||Member|
|Mateusz Koptyra||Children’s Hospital of Philadelphia||Member|
|Sarah Leary||Seattle Children’s Hospital||Member|
|Courtney Crane||Seattle Children’s Hospital||Member|
|Jim Olson||Seattle Children’s Hospital||Member|
|Andy Strand||Seattle Children’s Hospital||Member|
|Bonnie Cole||Seattle Children’s Hospital||Member|
|Rishi Lulla||Lurie Children’s||Member|
|Nitin Wadhwani||Lurie Children’s||Member|
|Amanda Saratsis||Lurie Children’s||Member|
|Joanna Phillips||UCSF, Benioff’s Children’s||Member|
|Sabine Mueller||UCSF, Benioff’s Children’s||Member|
|Michelle Monje||Stanford Medicine||Member|
|Gerald Grant||Stanford Medicine||Member|
|Brian Rood||Children’s National Health System||Member|
|Javad Nazarian||Children’s National Health System||Co-Chair|
|Eugene Hwang||Children’s National Health System||Member|
|Suresh Magge||Children’s National Health System||Member|
|Robert Keating||Children’s National Health System||Member|
|Jeff Greenfield||Weill Cornell Medicine||Member|
|David Pisapia||Weill Cornell Medicine||Member|
|Christopher Mason||Weill Cornell Medicine||Member|
|Olivier Elemento||Weill Cornell Medicine||Member|
|Praveen Raju||Weill Cornell Medicine||Member|