About CBTTC

About the CBTTC

The Children’s Brain Tumor Tissue Consortium (CBTTC) is a collaborative, multi-institutional research program dedicated to the study and treatment of childhood brain tumors. The CBTTC supports the research of new prognostic biomarkers and therapies for children with pediatric brain tumors. As part of this research effort, the CBTTC has developed a network of informatics and data applications which allow researchers from across the world to work together to discover cures. “Innovation through collaboration” is made possible by the CBTTC’s state-of-the-art biorepository as well as expertise of leaders in the field of biomedicine.

The CBTTC consists of 15 primary member institutions including: 1) Children’s Hospital of Philadelphia, 2) Seattle Children’s, 3) The Children’s Hospital of Pittsburgh and 4)Ann & Robert H. Lurie Children’s Hospital of Chicago, 5) Benioff Children’s Hospital (UCSF), 6) Stanford University/Lucile Packard Children’s Hospital, 7) Meyer Children’s Hospital Florence Italy, 8) Cancer Institute of New Jersey (Rutgers), 9)Weill Cornell Medicine Pediatric Brain and Spine Center, 10) Children’s National Health System, 11) Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center, 12) Children’s Hospital of Orange County: CHOC Children’s, 13) University of California Santa Cruz – Treehouse Childhood Cancer Initiative 14) The Beijing Tiantan Hospital Neurosurgery Center (Beijing, China) and 15) Genebank (Beijing Genomics Institute – Shenzhen, China).

The operations center of the CBTTC is located at Children’s Hospital of Philadelphia and integrates genomic and molecular research, biorepository management and support for the informatics platforms of the CBTTC. This infrastructure serves an important role in the CBTTC’s ability to provide free and open access to brain tumor data to researchers throughout the world.

CBTTC_Inforgraphic

Mission

The mission of the CBTTC is to find cures and improve treatments for children diagnosed with brain tumors.

To achieve this mission, the CBTTC collects high-quality brain tumor biospecimens and associated clinical data to facilitate the genomic analysis of biospecimens. Cell lines are developed and transplantable tumor models are then created from biopsy specimens. These models allow researchers to share their findings with other CBTTC member institutions and with the world-wide scientific community.

The CBTTC has established a collaborative multi-institutional tissue and data repository to enable the collection and analysis of the high-quality brain tumor biopsy specimens. In addition to specimen data, the repository also links to clinical data to provide a comprehensive snapshot of each unique tumor.

Additionally, the CBTTC is committed to the advancement of tissue-based research, allowing researchers throughout the world to access molecular analysis of brain tumor specimens. These initiatives will allow for improvements in therapeutic treatment of patients diagnosed with a brain tumor.

Executive Board

The Executive Board is the entity responsible for oversight of the CBTTC. Executive Committee Members are:

Name Institution Role
Jay Storm Children’s Hospital of Philadelphia Member
Adam Resnick Children’s Hospital of Philadelphia Scientific Co-Chair; PI from core institution
Angela Waanders Children’s Hospital of Philadelphia Member; PI from core institution
Michael Fisher Children’s Hospital of Philadelphia Member
Jena Lilly Children’s Hospital of Philadelphia Member
Ian Pollack The Children’s Hospital of Pittsburgh Member; PI from core institution
Ron Hamilton The Children’s Hospital of Pittsburgh Member
Sarah Leary Seattle Children’s Hospital Member; PI from core institution
Russ Geyer Seattle Children’s Hospital Member
Stewart Goldman Ann and Robert H. Lurie Children’s Hospital of Chicago Member
Rishi Lulla Ann and Robert H. Lurie Children’s Hospital of Chicago Executive Chair; PI from core institution
Jason Fangusaro Ann and Robert H. Lurie Children’s Hospital of Chicago Member
Joanna Phillips UCSF Benioff Children’s Hospital Member; Co-PI from core institution
Sabine Mueller UCSF Benioff Children’s Hospital Member; Co-PI from core institution
Brian Rood Children’s National Health System Member; Co-PI from core institution
Javad Nazarian Children’s National Health System Scientific Co-Chair; Co-PI from core institution
Gerald Grant Stanford Medicine Member; PI from core institution
Michelle Monje Stanford Medicine Member; Co-PI from core institution
Jeff Greenfied Weill Cornell Medicine Member; PI from core institution
Anita Nirenberg Children’s Brain Tumor Foundation (CBTF) Member; CBTF representative/ Community representative

Scientific Committee

The CBTTC Scientific Committee acts as a body that provides oversight for the functioning of the CBTTC. This oversight includes the assessment and approval of specimen and data requests, recommendations regarding specimen analysis and storage, and review and approval of all proposed posters, abstracts, publications, etc. utilizing CBTTC Repository specimens and data.

Name Institution Role
Sameer Agnihotri The Children’s Hospital of Pittsburgh Member
Kimberly Diamond The Children’s Hospital of Pittsburgh Member
Ronald Hamilton The Children’s Hospital of Pittsburgh Member
Baoli Hu The Children’s Hospital of Pittsburgh Member
Gary Kohanbash The Children’s Hospital of Pittsburgh Member
Ian Pollack The Children’s Hospital of Pittsburgh Member
Mateusz Koptyra Children’s Hospital of Philadelphia Member
Adam Resnick Children’s Hospital of Philadelphia Co-Chair
Mariarita Santi-Vicini Children’s Hospital of Philadelphia Member
Jay Storm Children’s Hospital of Philadelphia Member
Angela Waanders Children’s Hospital of Philadelphia Member
Bonnie Cole Seattle Children’s Hospital Member
Courtney Crane Seattle Children’s Hospital Member
Sarah Leary Seattle Children’s Hospital Member
Jim Olson Seattle Children’s Hospital Member
Andy Strand Seattle Children’s Hospital Member
Oren Becher Ann & Robert H. Lurie Children’s Hospital of Chicago Member
Rishi Lulla Ann & Robert H. Lurie Children’s Hospital of Chicago Member
Amanda Saratsis Ann & Robert H. Lurie Children’s Hospital of Chicago Member
Nitin Wadhwani Ann & Robert H. Lurie Children’s Hospital of Chicago Member
Joanna Phillips UCSF Benioff Children’s Hospital Member
Sabine Mueller UCSF Benioff Children’s Hospital Member
Michelle Monje Lucile Packard Children’s Hospital Stanford Member
Gerald Grant Lucile Packard Children’s Hospital Stanford Member
Eugene Hwang Children’s National Health System Member
Robert Keating Children’s National Health System Member
Suresh Magge Children’s National Health System Member
Javad Nazarian Children’s National Health System Co-Chair
Brian Rood Children’s National Health System Member
Jeff Greenfield Weill Cornell Brain and Spine Center Member
David Pisapia Weill Cornell Brain and Spine Center Member
Christopher Mason Weill Cornell Brain and Spine Center Member
Olivier Elemento Weill Cornell Brain and Spine Center Member
Praveen Raju Weill Cornell Brain and Spine Center Member
Holly Beale University of Santa Cruz: Treehouse Childhood Cancer Initiative Member
Olena Morozova University of Santa Cruz: Treehouse Childhood Cancer Initiative Member
Sofie Salama University of Santa Cruz: Treehouse Childhood Cancer Initiative Member
Anna Maria Buccoliero Meyer Children’s Hospital (Florence, Italy) Member
Chiara Caporalini Meyer Children’s Hospital (Florence, Italy) Member
Mirko Scagnet Meyer Children’s Hospital (Florence, Italy) Member

Organization

CBTTC Organization